SPLENDA No Calorie Sweetener is made from sugar, so it tastes like sugar. Its outstanding safety profile makes Splenda Sweetener Products an excellent choice for people with weight-related conditions or diabetes. Read the facts about SPLENDA Brand Sweetener, the brand name for sucralose, that is made from a process that begins with sugar. The sucralose safety profile addresses claims of side effects, safety, and dangers of Splenda.